|
| Stillgelegte Projekte |
| Biochemical Library |
 |
Die Forschung in unserem Labor versucht, Proteine, die fundamentalen Moleküle der Biologie, und ihr Zusammenspiel mit anderen kleineren molekularen Substraten zu untersuchen.
Es werden momentan drei große, unterschiedliche Ziele verfolgt:
1.) um Proteinstrukturen von Membranproteinen zu ermöglichen, für Behandlungen von großen makromolekularen Komplexen wie z.B. Viren,
2.) Proteine mit neuartigen Strukturen zu entwickeln, und/oder neue Annäherungen für Proteinbehandlungen zu erforschen und unser Verständnis von Proteinfaltungen zu vertiefen,
3.) die Beziehung zwischen chemischen Strukturen und biologischer Aktivität zu verstehen, um bessere und effizientere Medikamente zu entwickeln.
Die momentane Forschung fokussiert sich auf:
a) Drogenentwicklung für neurodegenerative Störungen und Krankheiten inklusive Schizophrenie, Alzheimer und Parkinson,
b) die strukturellen Determinanten von antidepressiven Bindungen zu Neurotransmitter-Transportern zu verstehen,
c) Herzrhythmusstörungen verursacht durch komplexes Zusammenspiel von Kaliumregulationen und Drogen-Benutzung,
d) Multidrogen-Widerstand von Krebs und bakteriellen Zellen in Bezug auf Transport-Proteine, und
e) strukturelle Basis von Vireninfektionen und Antikörper-Aktivität. |
| Status: |
beendet / Scheduler: |
| Homepage: |
http://boinc.vanderbilt.edu/bcl/ |
| Teamseite: |
https://boinc.vanderbilt.edu/bcl/team_display.php?teamid=11 |
| Statistiken: |
Credits: 3727.69/ RAC: 150.06 / Team-Stats:  / Team-Rankings:   |
| Diskussionsthema: |
Alles rund um BCL (Biochemical Library) |
| Optionen: |
Anmelden / Team beitreten |
| Verfügbare Plattformen: |
 |
| Letzte News vom Projekt: |
Leider nicht verfügbar |
| Letzte Forenbeiträge: |
07.04.2012, 20:51 Uhr
von DoctorNow | BCL wurde vorübergehend auf Eis gelegt, das ist auf der Homepage zu finden:
| Zitat: | Thanks for your interest into the Biochemical Library (BCL) project.
Unfortunately we have to disable the Boinc server for BCL for now. We do currently not have sufficient resources that would allow us to maintain and further improve the Boinc server. We plan to reactivate the Boinc server as soon as we can continuously manage it.
We will announce new plans and updates on the Meilerlab website. |
Ich leg das Projekt dann mal still... | 04.11.2010, 17:00 Uhr
von Cori | Am 02.11. gab's einen kurzen Post von Jens Meiler, dem Labor-Cheffe zu den Projekt-Zielen:
| Zitat: | Hi all, this is Jens Meiler. I am principal investigator of the Meiler laboratory (www.meilerlab.org) which develops the BCL. I would like to thank all of you for your interest in our research and our BOINC project. I would like to give a brief summary of what areas of research we are interested in and how you can help us through BOINC to achieve our research goals:
Research in our laboratory seeks to fuse computational and experimental efforts to investigate proteins, the fundamental molecules of biology, and their interactions with small molecule substrates, therapeutics, or probes. We develop computational methods with three major ambitions in mind: 1) to enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses; 2) design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways, and 3) understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs. Crucial for our success is the experimental validation of our computational approaches which we pursue in our laboratory or in collaboration with other scientists.
Current research applications focus on new approaches to a) drug and probe development for neurodegenerative disorders and diseases including Schizophrenia, Alzheimer's, and Parkinson’s, b) understanding the structural determinants of antidepressant binding to neurotransmitter transporters, c) cardiac arrhythmia as caused by the complex interplay of potassium channel regulation and drug interactions, d) multidrug resistance in cancer and bacterial cells related to multidrug transporter proteins, and e) structural basis of viral infections and antibody activity.
The BioChemical Library (BCL) is our primary venue of testing new algorithms and ideas. We plan to solicit your help through BOINC for many of the aforementioned projects by letting the BCL run on your computers. Right now we are only in the initial phase and focus on a single application: protein folding.
We implemented an exciting new algorithm for protein folding into the BCL. We expect that it will be superior for folding large and membrane proteins, many of which are important targets for therapeutics. To verify this expectation we need to complete a benchmark - folding 54 proteins at least 100,000 times possible up to 1,000,000 times. We plan to post these jobs to BOINC shortly. Thanks again for helping us and I will keep you updated once we get results... |
| 02.11.2010, 18:20 Uhr
von DoctorNow | Es gibt wieder einen Satz BCL-WUs! Hab schon einige abgegriffen.  |
|
| Aktualisiert: |
07.04.2012, 20:53 Uhr |
|
Diese Seite ist Teil der Homepage von BOINC@Heidelberg.
|
| Top Team-Länder |
 | 1.800.906.919 |  | 227.565.686 |  | 12.424.952 |  | 12.381.821 |  | 3.634.698 |
Komplette Liste |
| Serverzeit |
| 19.05.2013, 20:18 Uhr. |
|
|
